Flutamide-induced hypospadias in rats: A critical assessment
نویسندگان
چکیده
منابع مشابه
the effect of aqueous extract of garlic on formalin-induced pain in male rats
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15 صفحه اولFlutamide-induced hepatotoxicity
Abstract. – OBJECTIVE: Flutamide (FLU) is a non-steroidal antiandrogen drug approved for the treatment of advanced prostate cancer. While this indication limits the use to male patients, FLU is widely prescribed to women, off-label, for the treatment of polycystic ovary syndrome (POCS) related hirsutism and acne. According to the literature, its assumption is associated with a higher incidence ...
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flutamide is a non-steroidal antiandrogen commonly used in the treatment of prostate cancer. severe hepatotoxicity occurs in few patients, yet may be fatal. to date, none of the reported cases of flutamide hepatotoxicity has demonstrated thrombocytopenia and chronic liver disease. we report the case of a 55-year-old male with prostatic adenocarcinoma who developed liver failure after six months...
متن کاملMetabolite profiles of flutamide in serum from patients with flutamide-induced hepatic dysfunction.
Hepatic dysfunction due to flutamide administration has been reported and this side effect often limits the use of the agent. The prediction of flutamide-induced hepatotoxicity is attributed to the proper use of the antiandrogen. In this study, we investigated whether hepatic dysfunction could be assessed by the metabolite profile in serum from patients receiving this drug. Serum samples were o...
متن کاملHypospadias in goats
Hypospadias is an uncommon congenital defect of urinary tract in farm animals. This defect has been recorded rarely in calves, lambs and foals in the world. The aetiology of hypospadias is not well understood, it seems to be multifactorial and may be related to genetic, endocrinological, and environmental factors. During April to October 2007, twenty-four goat kids with sings of hypospadias wer...
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ژورنال
عنوان ژورنال: Differentiation
سال: 2017
ISSN: 0301-4681
DOI: 10.1016/j.diff.2016.12.001